FIGURE 3.

CR conservation of miR changes across species and tissues. CR and starvation are able to upregulate or downregulate miR signatures in (A) Caenorhabditis elegans, (B) Drosophila melanogaster, (C) rodents (Rattus norvegicus and Mus musculus), and (D) Rhesus macaques (Macaca mulatta) and humans (Homo sapiens). miR signatures associated with CR are involved in antiaging pathways such as immuno-metabolic regulation in different peripheral and central tissues. CR, caloric restriction; miR, the mature for of the miRNA; mir, the pre-miRNA and the pri-miRNA; *, asterisk following the name indicate the mature species found at low levels from the opposite arm of a hairpin.