Table 3.
Pathologic features of PGR fusion-positive uterine sarcomas
| Morphology | Immunohistochemical profile | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Size, cm | Spindled | Rhabdoid | Myxoid | MI | LVI | Necrosis | CD10 | Desmin | ER | PR | HMB45 | Fusion status |
| 1* | 5 | + | + | + | 19 | − | − | 0 | 4 | 4 | 4 | 0 | NR4A3-PGR |
| 2 | 12 | + | + | + | 9 | − | − | 0 | 2 | 4 | 4 | NP | NR4A3-PGR |
| 3 | 3 | + | + | + | 4 | − | − | 0 | 4 | 4 | 4 | 0 | NR4A3-PGR |
| 4 | 15 | − | + | − | 12 | + | − | 0 | 3 | 3 | 4 | 0 | PGR rearrangement only |
| 5 | 4 | + | + | − | 10 | + | − | 0 | 3 | 4 | 4 | NP | NR4A3-PGR |
| 6 | 27 | + | + | − | 10 | − | + | NP | 3 | 4 | 4 | 0 | PGR rearrangement only |
F indicates focal; HPF, high power field; LVI, lymphovascular invasion; MI, mitotic index (# per 10 high power fields); NP, not performed.
*
Index case subjected to RNA sequencing.