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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Ann Neurol. 2019 Mar 30;85(6):934–942. doi: 10.1002/ana.25461

Table 1.

Human pathology: multiple sclerosis cases

Case Clinical data Block
#
Lesion Lesion
pathological stage
Lesion max
diameter/ area*
# MRI-
prominent
central veins
1 59-year-old man with progressive MS (EDSS 6.5; disease duration: 21 years; untreated at time of death; cause of death: embolic brainstem stroke; PMI: 9 hours) 1 1 frontal periventricular Chronic active/slowly expanding 11.6 mm/52.7 mm2 1
2 2 frontal periventricular partially confluent lesions Chronic active/slowly expanding 9.5 mm/49.4 mm2 and 6.6 mm/20.5 mm2 2
3 1 occipital leukocortical Chronic active/slowly expanding 9.4 mm/30.6 mm2 2
4 1 leukocortical occipital Chronic active/slowly expanding 13.4 mm/81.3 mm2 2
5 1 frontal WM Chronic active/slowly expanding 8.5 mm/35.0 mm2 1
6 1 parieto-occipital periventricular Chronic active/slowly expanding 10 mm/51.5 mm2 4
2 68-year-old woman with progressive MS (EDSS 7.5; disease duration: 20 years; on treatment with natalizumab; cause of death: infratentorial PML; PMI: 19 hours) 7 1 frontal periventricular Chronic inactive 11.3 mm/110.5 mm2 3
8 1 parietal periventricular Chronic inactive 7.0 mm/40.5 mm2 2
3 60-years-old man with progressive MS (EDSS 7.5; disease duration: 16 years; on treatment with natalizumab; cause of death: sepsis; PMI: 7hours) 9 1 occipital WM Chronic inactive 5.3 mm/16.1 mm2 1
10 1 frontal WM Remyelinated/ Shadow plaque 3.1 mm/5.2 mm2 1
11 1 frontal periventricular Remyelinated/ Shadow plaque 5.9 mm/17.5 mm2 1
12 1 frontal periventricular Chronic inactive 7.8 mm/24.7 mm2 1
13 1 frontal WM Remyelinated/ Shadow plaque 3.6 mm/17.2 mm2 1
4 68-year-old woman with progressive MS (EDSS 7; disease duration: 30 years; untreated at time of death; cause of death: sepsis; PMI: 89 hours) 14 1 parietal periventricular Chronic inactive 11.7 mm/87.9 mm2 1
15 2 frontal lesions Chronic inactive 5.6 mm/12.5 mm2and 6.2 mm/16.3 mm2 2

Abbreviations: MS=multiple sclerosis, WM=white matter; PMI=post-mortem interval.

*

Lesion maximum diameter and area were measured on LFB or PLP myelin staining. In leukocortical lesions, lesion area refers only to WM demyelinated area.