Table 1.
Human pathology: multiple sclerosis cases
| Case | Clinical data | Block # |
Lesion | Lesion pathological stage |
Lesion max diameter/ area* |
# MRI- prominent central veins |
|---|---|---|---|---|---|---|
| 1 | 59-year-old man with progressive MS (EDSS 6.5; disease duration: 21 years; untreated at time of death; cause of death: embolic brainstem stroke; PMI: 9 hours) | 1 | 1 frontal periventricular | Chronic active/slowly expanding | 11.6 mm/52.7 mm2 | 1 |
| 2 | 2 frontal periventricular partially confluent lesions | Chronic active/slowly expanding | 9.5 mm/49.4 mm2 and 6.6 mm/20.5 mm2 | 2 | ||
| 3 | 1 occipital leukocortical | Chronic active/slowly expanding | 9.4 mm/30.6 mm2 | 2 | ||
| 4 | 1 leukocortical occipital | Chronic active/slowly expanding | 13.4 mm/81.3 mm2 | 2 | ||
| 5 | 1 frontal WM | Chronic active/slowly expanding | 8.5 mm/35.0 mm2 | 1 | ||
| 6 | 1 parieto-occipital periventricular | Chronic active/slowly expanding | 10 mm/51.5 mm2 | 4 | ||
| 2 | 68-year-old woman with progressive MS (EDSS 7.5; disease duration: 20 years; on treatment with natalizumab; cause of death: infratentorial PML; PMI: 19 hours) | 7 | 1 frontal periventricular | Chronic inactive | 11.3 mm/110.5 mm2 | 3 |
| 8 | 1 parietal periventricular | Chronic inactive | 7.0 mm/40.5 mm2 | 2 | ||
| 3 | 60-years-old man with progressive MS (EDSS 7.5; disease duration: 16 years; on treatment with natalizumab; cause of death: sepsis; PMI: 7hours) | 9 | 1 occipital WM | Chronic inactive | 5.3 mm/16.1 mm2 | 1 |
| 10 | 1 frontal WM | Remyelinated/ Shadow plaque | 3.1 mm/5.2 mm2 | 1 | ||
| 11 | 1 frontal periventricular | Remyelinated/ Shadow plaque | 5.9 mm/17.5 mm2 | 1 | ||
| 12 | 1 frontal periventricular | Chronic inactive | 7.8 mm/24.7 mm2 | 1 | ||
| 13 | 1 frontal WM | Remyelinated/ Shadow plaque | 3.6 mm/17.2 mm2 | 1 | ||
| 4 | 68-year-old woman with progressive MS (EDSS 7; disease duration: 30 years; untreated at time of death; cause of death: sepsis; PMI: 89 hours) | 14 | 1 parietal periventricular | Chronic inactive | 11.7 mm/87.9 mm2 | 1 |
| 15 | 2 frontal lesions | Chronic inactive | 5.6 mm/12.5 mm2and 6.2 mm/16.3 mm2 | 2 |
Abbreviations: MS=multiple sclerosis, WM=white matter; PMI=post-mortem interval.
*
Lesion maximum diameter and area were measured on LFB or PLP myelin staining. In leukocortical lesions, lesion area refers only to WM demyelinated area.