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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: J Am Chem Soc. 2019 May 2;141(19):7660–7664. doi: 10.1021/jacs.9b00349

Figure 2.

Figure 2.

Cytotoxicity of PSMα3 (5 μM total peptide) against HEK293FT cells as measured by an ATP-based luminescent viability assay. Rac. indicates preincubated in racemic form; rac* indicates L- and D- PSMα3 pre-incubated separately and mixed when added to cells. A: Peptides pre-incubated at 25 μM for 24 h before addition to cells. B: Peptides pre-incubated at 800 μM for 24 h before addition to cells. 0% and 100% toxicity represent averaged luminescence values of cells treated with vehicle or 400 μM Triton X-100, respectively, n = 3 independent experiments with at least three technical replicates per condition. Error bars represent standard error. For all conditions, p < 0.0001 compared to vehicle by One-way ANOVA with Bonferroni’s test unless denoted with not-significant (ns) in which case p > 0.05.