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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: Org Biomol Chem. 2019 May 15;17(19):4676–4688. doi: 10.1039/c9ob00581a

Figure 5. COPAs, a class of peptoid-inspired, conformationally constrained oligomers (PICCOs)43.

Figure 5

A. Synthesis of COPA oligomers follows the “sub-monomer” scheme developed by Zuckermann and colleagues for peptoids42. B. Scheme for the asymmetric synthesis of COPA sub-monomers. C. Cartoon illustrating the conformational preferences that cause COPAs to be relatively stiff foldamers. D. Predicted low energy conformers of a COPA tetramer depending on the absolute stereochemistry of each sub-unit. The blue balls represent the alkene atoms and the green balls heteroatoms. Reprinted with permission form ref. 44.