Fig. 5.

Anxiety-like behavioral testing illustrated inconsistent and confounded behavioral phenotypes in Snord116+/− mice. Anxiety-like behaviors were assessed in two gold standard assays: elevated plus-maze and light↔dark conflict. (A) During the elevated plus-maze, percent time spent on the open arm and (B) number of total arm entries (open+closed) were fewer in Snord116+/− mice as compared to Snord116+/ +. (C) In the light↔dark conflict assay, time spent in the dark chamber and (D) transitions between chambers did not differ between Snord116+/+ and Snord116+/− mice. *p < 0.05 versus Snord116+/+ by student’s unpaired t-test.