Figure 2.

Quantification of Rett syndrome epidermal nerve fiber density (RTT ENFd) compared to healthy control comparison group. (a) Group average and individual ENFd values between RTT patients and age‐, gender‐, body‐site matched comparison group. The average ENF density value estimates for the RTT sample was 42.0 ENF/mm (SD = 22.0, range = 12.2–60.3) and for the control sample was 27.3 ENF/mm (SD = 9.7; range = 15.3–41.1) [t = −1.72, p = 0.05, p < 0.10]. (b) Epidermal nerve fiber density values plotted by age for RTT patients and age‐, gender‐, body‐site matched comparison group. (c) Epidermal nerve fiber density values plotted by body surface area for RTT patients and age‐, gender‐, and body‐site matched comparison group