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. 2019 Apr 13;9(5):e01285. doi: 10.1002/brb3.1285

Table 1.

Peripheral quantification and immunohistochemistry from RTT 3 mm epidermal punch biopsy for each RTT case and healthy control

Case Age Site ENFd SP CGRP VIP Mast cell granulation Mast cell morphology
RTT1 12 Calf 39.3 5 20 0 0 Ovoid
RTT2 13 Calf 12.2 7 19 0 0 Elongated
RTT3 15 Calf 53.2 6 20 1 0 Elongated
RTT4 19 Calf 60.3 3 12 0 1 Elongated
HC 14 Calf 40.4 4 10 0 0 Ovoid
HC 12 Calf 28.2 6 13 0 0 Ovoid
HC 13 Calf 32.6 7 14 0 0 Ovoid
HC 12 Calf 19.4 7 7 0 0 Ovoid
HC 11 Calf 15.3 1 12 0 0 Elongated
HC 13 Calf 30.1 6 11 0 0 Ovoid
HC 17 Calf 22.1 3 15 0 0 Ovoid
HC 15 Calf 29.6 2 10 0 0 Ovoid

Age: years; Calf: posteromedial; ENFd: epidermal nerve fibers/3 mm; HC: healthy control; SP: substance P positive fibers/3 mm; CGRP: calcitonin gene‐related peptide positive fibers/3 mm; VIP: vasoactive intestinal peptide positive fibers/3 mm; Mast cell granulation: 0: intact/no degranulation; 1: minimal degranulation; RTT: Rett syndrome.