Figure 4.

In Vivo Protection against ZIKV Challenge in Rhesus Macaques following the Administration of DMAb-ZK190 or Naive Control

(A) Overview of the injection regimen in rhesus macaques. DMAbs were administered in 3 sequential administrations on days 0, 3, and 6, and serum was collected serially throughout the study. Macaques were challenged with 10⁴ PFU ZIKV strain PRVABC59 on day 0. (B) DMAb-ZK190 (n = 5) serum human IgG levels during the course of the challenge experiment. (C) Naive control (n = 5) serum human IgG levels during the course of the challenge experiment. (D) Serum ZIKV viral loads in DMAb-ZK190-administered macaques following challenge (n = 5). (E) Serum ZIKV viral loads in naive control macaques following challenge (n = 5). For each experiment, “n” refers to biological replicates.