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. 2019 May 15;4:17. doi: 10.1038/s41541-019-0111-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Intracellular HA distribution in human MDMs exposed to H1-VLPs or soluble H1. a HA internalization and degradation by MDMs pulsed with either H1-VLPs or soluble H1. The amount of internalized protein evaluated by the intensity of HA immunofluorescence per cell area on confocal microscopy images. Data from 9 experiments were analyzed. b Segmentation ICCS analysis of the HA endosomal distribution in MDMs pulsed (15 min) with either H1-VLPs or soluble H1 shows HA fluorescence intensity (top), cluster density (number of fluorescent particles per µm²—middle) and degree of HA aggregation (bottom). Based on 7 experiments. Bar graphs present mean ± standard deviation (S.D.); box and whisker plot presents the minimum, maximum, median, and 25th and 75th percentiles. *p < 0.05, ***p < 0.001, ****p < 0.0001 (one-way ANOVA followed by Tukey’s multiple comparisons post-test)