Table 3.

Meta-analysis of signals of bacterial association

Gene ID	Gene name	OR (NL)	p-value (NL)	OR (SA)	p-value (SA)	Combined p-value
SPN23F05680	ldcB/dacB	1.39	2.8 × 10–19	1.13	9.6 × 10–8	5.4 × 10–21
SPN23F22240	pspC/cbpA	1.00	8.1 × 10–1	1.12	4.7 × 10–12	5.3 × 10–11
SPN23F08080	spnTVR hsdS	0.82	1.9 × 10–4	1.09	4.2 × 10–6	7.5 × 10–2
SPN23F17820	psrP	−2.27 (invasive) −0.14 (carriage)	<1 × 10–6	−2.61 (invasive) −2.62 (carriage)	4.5 × 10–4	<1 × 10–6
SPN23F10590	zmpD	1.17	8.6 × 10–13	1.12	2.5 × 10–5	8.4 × 10–14
SPN23F09820	FM211187.3090	1.37	5.0 × 10–23	1.30	1.9 × 10–33	3.4 × 10–54
SPN23F05670	FM211187.1804	1.47	1.8 × 10–30	1.22	2.9 × 10–25	8.3 × 10–51
SPN23F04740	ecsA	1.20	1.8 × 10–7	1.11	9.7 × 10–4	1.8 × 10–8
SPN23F11460	mcrB	1.45	3.7 × 10–8	1.11	9.5 × 10–5	1.2 × 10–6

As in Table 2, showing behaviour of signals in The Netherlands (NL) and South African (SA) cohorts individually. The p value is from meta-analysis of the two cohorts using METAL to compute a combined z value, so is different from the p value in Table 2, which was computed by applying an LMM to all samples

OR odds ratio