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. 2019 May 15;9:7438. doi: 10.1038/s41598-019-43932-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Stability, oligomerization and structural characterization of PTPN3-PDZ. (A) Far-UV CD spectrum (195–240 nm) of PTPN3-PDZ. The experimental spectrum of PTPN3-PDZ and the best fit obtained with the CONTINLL algorithm are represented as black and red lines, respectively. (B) Superimposed ¹H, ¹⁵N HSQC spectra of PTPN3-PDZ (black) and PTPN3-PDZ_Next (red). (C) DSC thermograms of PTPN3-PDZ unbound and complexed to PBM peptides. Free PTPN3-PDZ curve is shown as a black line, and PTPN3-PDZ complexed to p38γ PBM, HBVc PBM and HPV16E6 PBM and HPV18E6 PBM curves are shown as yellow, purple, green and red lines, respectively. The DSC thermogram of free PTPN4-PDZ is colored in blue. (D) Sedimentation coefficient distributions of PTPN3-PDZ_Next unbound and complexed to viral PBM peptides. The black, red, green and purple lines correspond to PTPN3-PDZ_Next unbound and complexed to HPV18E6PBM, HPV16E6 PBM and HBVc PBM, respectively.