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. 2019 May 15;9:7438. doi: 10.1038/s41598-019-43932-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Structural comparison of the X-ray structure of PTPN3-PDZ_Next bound to HPV16E6 PBM with PTPN4-PDZ complexed to Cyto8retev, and with the CS-ROSETTA model of PTPN3-PDZ. (A) Clustalw2 alignment of PTPN3-PDZ (top) and PTPN4-PDZ (bottom). (B) Superposition of the structures of PTPN3-PDZ_Next bound to HPV16E6 PBM (light green/green) with PTPN4-PDZ bound to Cyto8retev (PDB 5EYZ) (light blue/blue). (C) Superposition of PTPN3-PDZ_Next bound to HPV16E6 PBM (light green/green) with the CS-ROSETTA model of PTPN3-PDZ (pink).