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. 2019 May 15;9:7414. doi: 10.1038/s41598-019-43576-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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UUO-induced vascular leak co-localizes with interstitial ATX. (a) Estimation of renal vascular permeability by extravasation of Evans Blue dye (EBD). Gross appearance of representative kidneys 10 days after UUO surgery and 30 min after Evans Blue injection. (b) Indices of Evans Blue leakage into non-ligated kidneys and ligated kidneys (n = 5 mice/group). Data are expressed as mean Evans Blue index ± SEM. (c,d) The leaked area of injected FITC-Dextran (500 kDa) in kidneys obtained 10 days after UUO (n = 5 mice/group). Data are expressed as mean ± SEM. (e) Co-localization of injected FITC-Dextran (green) and ATX (red) in kidneys. Representative tissue sections are shown (magnification x 200). Arrows indicate the intact blood vessels. Bars, 100 μm.