Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 15;9:7414. doi: 10.1038/s41598-019-43576-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

ATX-LPA₁ signaling regulates renal fibroblast migration. (a) Relative mRNA levels of LPA receptors in renal fibroblasts. ΔΔCT method was used to calculate relative gene expression of LPA receptors with β2MG being the internal control. Data are expressed as mean ± SEM. (b) Representative pictures of migrated renal fibroblasts in response to 10 μM LPC with indicated concentrations of recombinant ATX. Bars, 100 μm. (c) The addition of ATX to LPC enhanced renal fibroblast migration in an ATX concentration-dependent manner. (n = 3 cell preparations/group). (d,e) Pre-treatment with PAT-048 (d) or AM152 (e) suppressed renal fibroblast migration induced by ATX and LPC in a concentration-dependent manner. (n = 3 cell preparations/group). Data are expressed as mean ± SEM.