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. 2019 May 15;9:7419. doi: 10.1038/s41598-019-43969-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Biodistribution study of Rm-⁸⁹Zr-HMSNs in CT-26 tumor-bearing female Balb/c mice (n = 3 per group). (B) Small animal PET images of CT-26 tumor-bearing female Balb/c mice with ⁸⁹Zr-HMSNs (top), Rm-⁸⁹Zr-SNPs (middle) and Rm-⁸⁹Zr-HMSNs (bottom). PET images were obtained for 1 week after tail intravenous injection of ⁸⁹Zr labelled NPs.