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Adrecizumab decreases ROS production. Adrecizumab decreased ROS production in the septic myocardium within 3 h. Dihydroethidium (DHE; Sigma-Aldrich) staining was used to evaluate the in situ levels of superoxide anion in the myocardium. Data are expressed as a percentage of region of interest (percent of ROI). Kruskal-Wallis test followed by Dunn’s multiple comparison test was used. *p < 0.05 and ***p < 0.001
