FIG 3.

Rabbit nanosponges neutralized PFTs and protected the retina from PFT-mediated damage in a sterile endophthalmitis model. Right eyes were injected with either 0.5 μl of rabbit nanosponge (NS)-treated B. cereus (BC), methicillin-resistant S. aureus (MRSA), methicillin-sensitive S. aureus (MSSA), S. pneumoniae (SP) supernatant, or untreated supernatant. Eyes were then harvested 24 h later and processed for hematoxylin and eosin staining. Images are representative of at least 3 eyes from 2 independent experiments. Control uninjected mouse eyes did not exhibit inflammatory infiltrate in either the anterior or posterior chambers, and the corneas and retinal layers appeared normal. Eyes injected with BC, MRSA, MSSA, and SP typically showed retinal and corneal edema and cellular infiltrate and fibrin deposition in the anterior and posterior segments. In eyes injected with rabbit NS-treated BC, MRSA, MSSA, and SP supernatant showed less anterior and posterior chamber infiltrate, less retinal edema, intact retinal layers, and normal corneas.