FIG 7.

Neutrophil defects impact immunity to C. albicans but not C. parapsilosis infection. (A) Tg(mpx:mCherry-2A-Rac2D57N) (D57N) zebrafish and their wild-type (WT) siblings were infected at 4 dpf and monitored for 4 days. Survival curves are based on data pooled from 3 independent experiments. (B) qPCRs of cohorts of 10 fish, in 3 independent experiments, performed as described in the legend of Fig. 2. The median log₂-fold changes relative to vehicle-injected fish are plotted. Gray bars, WT; red bars, D57N mutant; dotted bars, C. parapsilosis-infected fish; solid bars, C. albicans-infected fish. Notations above individual bars indicate differences between Candida-infected and vehicle-injected groups. Notations above brackets indicate differences between WT and D57N fish. Statistics are described in Materials and Methods (*, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ns, not significant [P > 0.05]).