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Bortezomib is effective when added prior to 3 h p.i. HSV-1 KOS was added to Vero cells (MOI of 0.001). At the indicated times p.i., 200 nM bortezomib was added. At 18 to 24 h p.i., plaques were enumerated. The values representing mock-treated samples were set to 100%. Data presented are representative of results from three experiments. Error bars, SEM.
