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. 2019 May 14;10(3):e00866-19. doi: 10.1128/mBio.00866-19

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Copyright © 2019 Gruffaz et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 6 — XPO1 inhibition-induced p53 activation in PML-NBs depends on p62 nuclear accumulation in AGS and HUH7 cells. (A) Expression of PML and p62 in AGS, HUH7, MM, and KMM cells after treatment with 1 µM KPT-8602 for 24 h analyzed by immunofluorescence assay. The sections were counterstained with DAPI, and pictures were taken with a confocal microscopy (magnification, ×600). (B) Expression of p62 in AGS and HUH7 cells following siRNA knockdown analyzed by Western blotting. (C) Analysis of p-p53 in AGS and HUH7 cells after treatment with 1 µM KPT-8602 for 24 h following siRNA knockdown of p62 by Western blotting.