Table 2.

Model construction process

Model ID	OFV	ΔOFV	P value	Modeling
1	617.755	–	–	Basic model
Covariates on CL
2	606.197	− 11.558	P < 0.05	Add CLCR on CL in model 1
3	608.973	− 8.782	P < 0.05	Add AGE on CL in model 1
4	609.196	− 8.559	P < 0.05	Add WT on CL in model 1
Forward inclusion
5	601.501	− 4.696	P < 0.05	Add AGE on CL in model 2
6	602.416	− 3.781	P > 0.05	Add WT on CL in model 2
Backward elimination
7	608.973	7.472 > 6.64	P < 0.01	Sub CLCR on CL in model 6
8	606.197	4.696 < 6.64	P > 0.01	Sub AGE on CL in model 6
				Model 2 as final model

WT weight, CL_CR creatinine clearance rate, OFV objective function value