Figure 2.

Amygdala and ACC Functional Coupling Changes after Stimulation

(A–C) Activity coupling between amygdala (in yellow on the coronal view) and the rest of the brain in the no stimulation (control) condition (A), after amygdala TUS (B), and after ACC TUS (C).

(D–F) Activity coupling between ACC (outlined in black) and the rest of the brain in the no stimulation (control) condition (D), after amygdala TUS (E), and after ACC TUS (F). Hot colors indicate positive coupling (Fisher’s z). Functional connectivity from TUS-targeted regions is highlighted by black boxes. Each type of TUS had a selective effect on the stimulated area; amygdala coupling was strongly changed by amygdala TUS only (B), and ACC coupling was strongly changed by ACC TUS only (F).

(G) Connectivity fingerprint representation of the strength of activity coupling between amygdala and other brain areas in control animals (blue), after amygdala TUS (yellow), and after ACC TUS (red).

(H) Activity coupling between ACC and the rest of the brain in control animals (blue), after ACC TUS (red), and after amygdala TUS (yellow). Each type of TUS had a selective effect on the stimulated area; amygdala coupling was strongly affected by amygdala TUS (the yellow line is closer to the center of the panel than the blue line), and ACC coupling was strongly disrupted by ACC TUS (the red line is closer to the center of the panel than the blue line). SEM is indicated by shading around each line.

(I) The regions of interest constituting the fingerprints depicted on lateral, medial, orbital, and dorsal views.