Figure 4.

Intrinsic membrane properties of dLGN interneurons in WT and math5^−/− interneurons. Examples of voltage responses to hyperpolarizing (−120 pA) and depolarizing (150 pA) current step pulses from interneurons at different postnatal weeks (1–4) for WT (left) and math5^−/− (right) interneurons; WT: RMP, −55 to 60 mV; math5^−/−: RMP, −45 to 50 mV. For WT mice, interneurons exhibit a strong V_sag in response to hyperpolarizing pulses following the termination of the current pulse. Membrane depolarization evokes a train of action potentials. In math5^−/− mice, interneuron responses remain relatively immature.