Figure 7.

Pattern of spontaneous inhibitory activity in relay neurons in WT and math 5^−/− mice. A, B, Examples of WT (A) and math5^−/− (B) dLGN relay neurons (scale bar, 40 μm) and their corresponding sIPSC responses before and after bath application of the mGluR₅ agonist DHPG (50 μm). Black horizontal bars above histograms reflect post-drug analysis period. All other conventions are the same as in Figure 6. DHPG application leads to a sustained increase in IPSC activity in WT mice and little or no change in math5^−/− mice.