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. 2019 May 15;39(20):3832–3844. doi: 10.1523/JNEUROSCI.0881-18.2019

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Figure 5. — RIPK1 activation and mitochondrial fragmentation contributes to axonal degeneration by a cell-autonomous mechanism. DRG explants were damaged by axotomy or vinblastine (1 μm) treatment in the presence of Nec-1, Mdivi, or vehicle as a control, and analyzed after 12 h. A, B, Degeneration was evaluated in distal axons immunostained for NFH (A), quantitatively assessed, and represented as relative neurite integrity (B). Scale bar, 30 μm. Two-way ANOVA with post hoc Tukey, * indicates statistically significant compared with Ctrl; # indicates statistically significant compared with Veh.