Table 1.
Parameters for intrinsic excitability
| Input conductance (nS) | AP onset time (ms) | First spike latency (ms) | |
|---|---|---|---|
| Control (CA3-PC in SD rats; n = 9) | 3.74 ± 0.17 | 10.0 ± 0.16 | 469.1 ± 13.12 |
| TPEN (n = 16) | 4.73 ± 0.30 | 10.6 ± 0.4 | 640.2 ± 34.9 |
| 100 μm ZX1 (n = 16) | 4.83 ± 0.36 | 9.4 ± 0.2 | 599.6 ± 112.7* |
| 50 μm ZX1 (n = 5) | 5.27 ± 0.67 | 8.82 ± 0.2 | 591.7 ± 40.7* |
| Na3VO4 (n = 11) | 4.50 ± 0.25 | 11.03 ± 0.3 | 538.2 ± 35.0 |
| Anti-RPTPα antibody (LS-C80176–50) (n = 8) | 5.70 ± 0.33* | 10.2 ± 0.2 | 684.7 ± 55.8* |
| Anti-RPTPα antibody (07–472) (n = 5) | 6.35 ± 0.67* | 9.6 ± 0.2 | 740.6 ± 50.9*** |
| Nonimmunized antibody (n = 5) | 4.34 ± 0.4 | 8.1 ± 0.46 | 578.17 ± 58.46 |
| ZnCl2 supplement (n = 10) | 5.31 ± 0.32 | 11.0 ± 0.3 | 620.5 ± 32.85 |
| 8 ∼ 14 week-old mice (n = 10) | 5.25 ± 0.52 | 9.6 ± 0.8 | 554.1 ± 40.2 |
| ∼8- to 14-week-old mice + ZnCl2 (n = 5) | 6.46 ± 1.49 | 8.48 ± 0.8 | 566.2 ± 99.25 |
| ZnT3+/+ (n = 5)a | 3.52 ± 0.34 | 8.8 ± 0.8 | 493.8 ± 22.5 |
| ZnT3−/− (n = 10) | 3.62 ± 0.23 | 9.4 ± 0.5 | 502.3 ± 39.9 |
| ZnT3−/− and ZnCl2 supplement (n = 6) | 3.45 ± 0.09 | 8.3 ± 0.3 | 471.2 ± 37.9 |
Statistical values and significance for the effects of conditioning on Gin, AP onset time, and the first spike latency were determined at 30 min after conditioning; AP onset time and the first spike latency are defined in Hyun et al. (2013). All values are shown as the mean ± SEM. Statistical significance was tested in comparison with control values using one-way ANOVA and Bonferroni correction.
aData from ZnT3+/+ CA3-PCs were used for control of data from ZnT3−/− mice. Otherwise, data from Sprague Dawley rats were regarded as control.
*p < 0.05;
***p < 0.005.