Table 2.
Summary for the peak of IKD
| −40 mV (pA) | −30 mV (pA) | −20 mV (pA) | |
|---|---|---|---|
| Control (n = 5) | 129.18 ± 8.35 | 269.91 ± 31.75 | 459.99 ± 45.39 |
| 50 Hz AP train (n = 5) | 129.46 ± 20.73 | 292.20 ± 35.18 | 420.04 ± 43.49 |
| (p = 1.00) | (p = 1.00) | (p = 1.00) | |
| 50 Hz AP train + intracellular anti-RPTPα Ab (LS-C08176-50) (n = 5) | 65.04 ± 17.22 | 139.76 ± 18.21 | 218.74 ± 16.10 |
| (p = 0.03) | (p = 0.019) | (p < 0.001) | |
| 50 Hz AP train + intracellular anti-RPTPα Ab (07-472) (n = 5) | 47.22 ± 8.00 | 145.58 ± 7.94 | 224.92 ± 12.63 |
| (p = 0.003) | (p = 0.028) | (p < 0.001) | |
| 50 Hz AP train + extracellular 100 nm ZnCl2 (n = 5) | 24.83 ± 6.43 | 115.18 ± 26.18 | 203.28 ± 11.57 |
| (p < 0.001) | (p = 0.004) | (p < 0.001) | |
| One-way ANOVA | F(4,20) = 12.763 | F(4,20) = 10.107, | F(4,20) = 17.055, |
| (p < 0.001) | (p = 0.001) | (p < 0.001) |
Values are the mean SEM, unless otherwise indicated. The 30 μm 4-AP-sensitive D-type K+ current at the test potentials of −40, −30, and −20 mV. Statistical values and significance for the effects of various conditions described above on peak IKD current. Statistical significance was tested in comparison with control values using one-way ANOVA and Bonferroni correction.