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. 2019 May 8;10:464. doi: 10.3389/fphar.2019.00464

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Copyright © 2019 Wan, Yang, McReynolds, Barnych, Wagner, Morisseau, Hwang, Sun, Blöcher and Hammock.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LC-MS precursor ion scan analysis of TPPU and its metabolites in rat urine extract. Metabolites in urine were extracted directly via protein precipitation by addition of acetonitrile. (A) Possible TPPU metabolites containing the intact 4-(trifluoromethoxy)aniline moiety in their structures were screened by precursor ion scan for m/z 176. (B) TPPU metabolites if formed without urea cleavage were screened by precursor ion scan for m/z 85. Insert: the retention time and corresponding m/z of isolated metabolites.