Table 5.
Partial rank correlation coefficients (PRCC) between the Latin Hypercube Samples of estimated parameters and the annual cumulative incidence of meningitis (sensitivity analysis)
| Model1-‘inv’ | Model2-‘transm’ | Model3-‘inv-transm’ | |||||
|---|---|---|---|---|---|---|---|
| Parameter | Short description | PRCCa | 95% Confidence interval | PRCC | 95% Confidence interval | PRCC | 95% Confidence interval |
| β0 | Meningococcal mean transmission rate | 0.76*** | 0.68–0.84 | 0.80*** | 0.75–0.86 | 0.91*** | 0.88–0.96 |
| a0 | Meningococcal mean invasion rate | 0.90*** | 0.86–0.96 | 0.84*** | 0.76–0.94 | 0.81*** | 0.75–0.89 |
| α | Rate of loss of carriage | −0.89*** | −0.93 to −0.86 | −0.49*** | −0.65 to −0.31 | −0.63*** | −0.75 to −0.54 |
| φ | Rate of loss of natural immunity | 0.80*** | 0.73–0.88 | 0.87*** | 0.82–0.93 | 0.90*** | 0.87–0.95 |
| θ | Calendar day of maximal invasion rate | 0.18 | −0.01 to 0.36 | 0.03 | −0.17 to 0.27 | −0.04 | −0.26 to 0.19 |
| εa | Seasonal forcing amplitude of invasion rate | −0.15 | −0.34 to 0.05 | NA | NA | −0.025 | −0.25 to 0.22 |
| εb | Seasonal forcing amplitude of meningococcal transmission rate | NAb | NA | 0.18 | 0.03–0.37 | −0.11 | −0.31 to 0.11 |
| S0 | Initial susceptibles’ proportion | 0.86*** | 0.81–0.93 | 0.73*** | 0.66–0.84 | 0.81*** | 0.74 to 0.90 |
| C0 | Initial carriers’ proportion | 0.09 | −0.08 to 0.33 | 0.11 | −0.095 to 0.28 | 0.22* | 0.04 to 0.40 |
Partial rank correlation coefficients estimates are significantly different than 0 at 0.05 level (*), and <10−10 level (***) two-sided P values. They quantify the statistical relationship between each parameter and the model output.
NA stands for not applicable to the model.