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. 2019 Jan 2;121(3):881–892. doi: 10.1152/jn.00536.2018

Fig. 4.

Fig. 4.

TRPV1 inhibitors do not alter tractus solitarii-evoked excitatory postsynaptic currents (TS-EPSCs) in normoxic (NORM) and chronic intermittent hypoxia (CIH)-exposed neurons of the nucleus of the solitary tract (nTS). A and B: example of TS-EPSCs in a NORM (A) and CIH-exposed (B) nTS neuron in artificial cerebrospinal fluid (aCSF) baseline and in the presence of the TRPV1 inhibitor capsazepine (CZP). Arrows depict time of TS stimulation. Note the minimal decrease in TS-EPSC with TRPV1 inhibition. Examples are overlay of 10 events each. C and D: group data demonstrating the TRPV1 inhibitors CPZ (C) and SB-366791 (SB; D) minimally altered TS-EPSCs compared with aCSF (2-way RM ANOVA, CPZ exposure: drug, P = 0.06; hypoxia, P = 0.27; drug × hypoxia, P = 0.33; SB exposure: drug, P = 0.01; hypoxia, P = 0.36; drug × hypoxia, P = 0.21). *P < 0.05 vs. aCSF with Bonferroni post hoc (CPZ: NORM and CIH, n = 4 each; SB: NORM, n = 9, CIH, n = 8).