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. 2019 Jan 2;121(3):881–892. doi: 10.1152/jn.00536.2018

Fig. 7.

Fig. 7.

TRPV1 inhibitors attenuate the elevated miniature excitatory postsynaptic currents (mEPSCs) after chronic intermittent hypoxia (CIH). A and B: examples of reduction in mEPSC events after TRPV1 inhibition with capsazepine (CPZ) in normoxic (NORM; A) and CIH-exposed (B) cells. Examples shown are a single trace. aCSF, artificial cerebrospinal fluid. C and D: mean mEPSC frequency data demonstrating CPZ (C) and SB-36679 (SB; D) tended to attenuate mEPSCs from aCSF control (C) in NORM neurons. Following CIH, CPZ and SB significantly decreased mEPSCs and returned their frequency to near NORM levels (2-way RM ANOVA, CPZ application: drug, P = 0.002; hypoxia, P = 0.24; drug × hypoxia, P = 0.11; SB application: drug, P = 0.0003; hypoxia, P = 0.06; drug × hypoxia × drug, P = 0.06). *P < 0.05, CPZ or SB vs. aCSF baseline with Bonferroni multiple comparison (CPZ: NORM, n = 6; CIH, n = 8; SB: NORM, n = 5; CIH, n = 7).