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. 2019 Jan 2;121(3):881–892. doi: 10.1152/jn.00536.2018

Fig. 9.

Fig. 9.

Asynchronous excitatory postsynaptic current (aEPSC) events do not increase in TRPV1−/− mice after chronic intermittent hypoxia (CIH). CIH increases aEPSC in TRPV1+/+ (A) but not TRPV1−/− (D) mice. Examples are overlays of 2 traces each. Insets are zoomed images of peak events. B and E: diary plots of the events shown in representative examples (events/100 ms). Events before tractus solitarii (TS) stimulation are fit with a linear regression, whereas events following TS stimulation are fit via nonlinear curve. C and F: TRPV1+/+ mice increased peak and average aEPSC events after CIH (2-way ANOVA: EPSC, P = 0.001; hypoxia, P = 0.09; EPSC × hypoxia, P = 0.61). In NORM TRPV1−/− mutant mice, TS stimulation (20 Hz) increased peak events, which were eliminated after CIH (2-way ANOVA: EPSC, P = 0.001; hypoxia, P = 0.04; EPSC × hypoxia, P = 0.02). Ave, average; Bsl, baseline. *P < 0.05; **P < 0.01; ****P < 0.0001 vs. baseline within NORM or CIH group with Bonferroni post hoc. $P < 0.05, CIH vs. NORM with Bonferroni post hoc (TRPV1+/+: NORM, n = 9; CIH, n = 12; TRPV1−/−: NORM, n = 14; CIH, n = 15).