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Distribution of mutations in 21 melanoma lymph node metastases and one PDX (melmet 389). Sequencing was performed using IonTorrent Oncomine (blue and cancer Hotspot (gray) panels. Mutation analysis was performed using the Torrent Suite Variant Caller version 5.9 and annotated using ANNOVAR as described in Materials and Methods. Response to Vemurafenib is shown in bottom bar; sensitive (green), resistant (red).
