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. 2019 May 13;12(7):932–950. doi: 10.1016/j.tranon.2019.04.005

Figure 2.

Figure 2

Chemical synthesis of DPS-2. (i) KOH, EtOH/H2O/EtOAc, RT, 18 hours, 85%, (ii) PPA, 85°C , 2 hours, (iii) Acetone, reflux, 1 hour, 61% (in two steps), (iv) SOCl2 / AlCl3, C6H5Cl, 75°C , 2 hours, DCM, 1 hour RT, 62%, (v) LAH, THF, 0°C , 45 min, 94%.