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. 2019 May 9;6(2):ENEURO.0031-19.2019. doi: 10.1523/ENEURO.0031-19.2019

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Copyright © 2019 Day et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — GLP-1 (9-36) treatment rescues hippocampal synaptic plasticity impairments in Ts65Dn mice. A, Acute hippocampal slices from WT+ Saline (n = 9), Ts65Dn + Saline (n = 10), WT+ GLP-1 (9-36) (n = 10), and Ts65Dn + GLP-1 (9-36) (n = 9) mice were stimulated with HFS to induce LTP at the CA3-CA1 synapse. Arrow indicates HFS. Two-way repeated-measures ANOVA revealed significant group (p < 0.05), time (p < 0.05), and group × time (p < 0.001) effects. At 90 min post-HFS, Tukey’s post hoc tests revealed Ts65Dn + Saline had significantly impaired LTP compared with GLP-1 (9-36)-treated Ts65Dn mice (p < 0.05) and saline- and GLP-1 (9-36)-treated WT mice (p < 0.001, p < 0.05). B, Measurement of fEPSP slope at 30, 60, and 90 min after HFS (*p < 0.05, **p < 0.01). C, Representative fEPSP traces at baseline and 90 min post-HFS. D, I/O curves were established by plotting fEPSP amplitudes against fiber volley amplitudes at increasing stimulus intensities in hippocampal slices from WT+ Saline (n = 9), Ts65Dn + Saline (n = 10), WT+ GLP-1 (9-36) (n = 9), and Ts65Dn + GLP-1 (9-36) (n = 9) mice. One-way ANOVA revealed no significant differences between groups at any time point. E, PPF in WT+ Saline (n = 9), Ts65Dn + Saline (n = 10), WT+ GLP-1 (9-36) (n = 9), and Ts65Dn + GLP-1 (9-36) (n = 9) mice. One-way ANOVA revealed no significant differences between groups at any time point.