Table 3.
Flavivirus cross-reactive T cell epitopes identified using HLA transgenic murine models, named in the same manner as the papers they were identified in with the exception of (*)NS52695.
| Epitope | Amino acid sequence | Viruses reported in | Mouse Strain | References |
|---|---|---|---|---|
| NS31682 | LPAIVREAI LPSIVREAL | DENV2/1/3 DENV4 | Ifnar1−/− HLA-B*0702 transgenic | (103) |
| NS31700 | APTRVVAAEM APTRVVASEM | DENV2/3/4 DENV1 | Ifnar1−/− HLA-B*0702 transgenic | (103) |
| NS32070 | KPRWLDARI RPKWLDARV | DENV2 DENV3 | Ifnar1−/− HLA-B*0702 transgenic | (103) |
| NS4b2280 | RPASAWTLYA HPASAWTLYA | DENV2/1/4 DENV1/3 | Ifnar1−/− HLA-B*0702 transgenic | (103) |
| NS52885 | TPRMCTREEF KPRLCTREEF | DENV2 DENV3 | Ifnar1−/− HLA-B*0702 transgenic | (103) |
| NS2a75 | RPALLVSFIF | ZIKV DENV2 | Ifnar1−/− HLA-B*0702 transgenic | (97) |
| NS3206 | APTRVVAAEM | ZIKV DENV2 | Ifnar1−/− HLA-B*0702 transgenic | (97) |
| NS3574 | KPRWMDARV | ZIKV DENV2 | Ifnar1−/− HLA-B*0702 transgenic | (97) |
| *NS52695 | RPGAFCIKVL | ZIKV DENV2 | Ifnar1−/− HLA-B*0702 transgenic | (97) |
| NS5539 | VPTGRTTW | ZIKV DENV2 | Ifnar1−/− HLA-B*0702 transgenic | (97) |
| Env P1 | IRCIGVSNRDFVEGMSGGTW FNCLGMSNRDFLEGVSGATW AHCIGITDRDFIEGVHGGTW MRCVGIGNRDFVEGLSGATW MRCIGISNRDFVEGVSGGSW MRCVGVGNRDFVEGLSGATW MRCVGVGNRDFVEGVSGGAW | ZIKV WNV YFV DENV1 DENV2 DENV3 DENV4 | AG129 HLA-DR1, DR15, DQ8 transgenic | (40) |
| Env P25 | ALVEFKDAHAKRQTVVVLGS HLVEFEPPHAATIKVLALGN LLVTFKTAHAKKQEVVVLGS RMVTFKVPHAKRQDVTVLGS | ZIKV YFV DENV1 DENV4 | AG129 HLA-DR15 transgenic | (40) |
| Env P41 | HRSGSTIGKAFEATVRGAKR FKKGSSIGKMFEATARGARR YKKGSSIGKMFEATARGARR | ZIKV DENV1 DENV3 | AG129 HLA-DR15 transgenic | (40) |
| Env P7 | YEASISDMASDSRCPTQGEA IEAKISNTTTDSRCPTQGEA IEAKLTNTTTESRCPTQGEP IEGKITNITTDSRCPTQGEA IEALISNITTATRCPTQGEP | ZIKV DENV1 DENV2 DENV3 DENV4 | AG129 HLA-DQ8 transgenic | (40) |
| Env P8 | DSRCPTQGEAYLDKQSDTQY KAACPTMGEAHNDKRADPAF DSRCPTQGEATLVEEQDANF ESRCPTQGEPSLNEEQDKRF DSRCPTQGEAVLPEEQDQNY | ZIKV WNV DENV1 DENV2 DENV3 | AG129 HLA-DQ8 transgenic | (40) |
In the original research publication the amino acid sequence was presumed to be ZIKV NS4b (NS4b426). However our sequence alignment studies show the peptide to be within the NS5 region and therefore the peptide was renamed in this review for the sake of clarity with the first amino acid being position 2695 of the polyprotein.