The effect of theobromine (TB) on memory performance assessed by the novel object recognition (NOR) test. The discrimination index (DI) for exploring the object A1, A2 (A); object A1, B (B); and object A1, C (C). Both DIs (Object A1, B and Object A1, C) were significantly greater in TB-fed rats (TB rats) in 2 trials. Values are the mean ± S.E.M. (n = 5 for each group). * p < 0.05, ** p < 0.01; significant difference between groups. Total exploration time for same object (object A1, A2) (D); total exploration time for each object (object A1, B) (E); and total exploration time for each object (object A1, C) (F). TB rats stayed significantly longer time at the new object B and C in 2 trials. Values are the mean ± S.E.M. (n = 5 for each group). * p < 0.05, ** p < 0.01; significant difference between A1 and B or C.