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The effect of theobromine (TB) on brain derived neurotrophic factor (BDNF) mRNA and protein levels. (A) Relative mRNA expression and (B) protein level in TB-fed rat (TB rats) of BDNF were significantly higher than those of control rats (CN rats) in the prefrontal cortex. Hippocampal BDNF protein levels did not differ between groups (Figure S2). Values are the mean ± S.E.M. (n = 6 for each group). * p < 0.05; significant difference between groups.
