Table 2.

List of ion channels genes showing differential expression in nevi vs. melanoma (p < 0.05), sorted according to the AUC value. The analysis was carried out in the GEO GDS1375 dataset.

No.	Gene Name	t Test Nevi vs. Melanoma	Ratio Melanoma vs. Nevi		AUC	No.	Gene Name	t Test Nevi vs. Melanoma	Ratio Melanoma vs. Nevi		AUC
1	ANO1	8.7 × 10−18	0.231		0.98	47	CACNB2	1.5 × 10−3	0.4388		0.73
2	KCNK7	1.8 × 10−17	0.081		0.94	48	TRPV6	1.9 × 10−3	0.576		0.65
3	SCNN1A	1.0 × 10−14	0.07		0.98	49	CLIC2	2.0 × 10−3	0.319		0.87
4	SCNN1B	1.4 × 10−14	0.313		0.96	50	SCN3A	2.2 × 10−3	0.382		0.64
5	GABRE	2.3 × 10−13	0.203		0.95	51	GRIN2A	2.3 × 10−3	0.619		0.69
6	GJB5	3.4 × 10−13	0.1277		0.97	52	CACNG4	2.6 × 10−3	1.317		0.74
7	CLIC1	1.9 × 10−12	1.738		0.95	53	GABRB1	3.0 × 10−3	0.698		0.69
8	KCND3	2.0 × 10−11	0.487		0.94	54	GJB4	3.7 × 10−3	0.588		0.63
9	KCNK1	8.6 × 10−11	0.269		0.93	55	CACNB4	4.3 × 10−3	0.474		0.66
10	GRIA1	8.7 × 10−11	0.1049		0.93	56	CACNA11	5.0 × 10−3	0.629		0.70
11	VDAC1	2.0 × 10−10	1.8		0.96	57	KCNK2	5.0 × 10−3	0.512		0.64
12	GJB3	2.1 × 10−10	0.2453		0.96	58	TRPC1	5.4 × 10−3	0.665		0.70
13	KCNN2	3.6 × 10−10	4.337		0.91	59	TRPC7	5.7 × 10−3	1.396		0.74
14	AQP1	5.5 × 10−10	0.268		0.84	60	GRIK1	6.3 × 10−3	1.885		0.72
15	ITPR3	1.1 × 10−9	2.311		0.93	61	GRIN2D	6.7 × 10−3	1.922		0.75
16	RYR1	1.8 × 10−9	0.2414		0.81	62	CLIC4	6.8 × 10−3	0.671		0.69
17	GJA1	2.1 × 10−9	0.086		0.98	63	CACNA1S	7.7 × 10−3	1.91		0.77
18	KCNJ13	1.9 × 10−8	0.266		0.86	64	CATSPER2	8.1 × 10−3	0.677		0.75
19	TRPV2	3.0 × 10−8	1.77		0.88	65	GABRP	8.1 × 10−3	0.3014		0.69
20	GJB1	3.4 × 10−8	2.643		0.93	66	GJA4	9.0 × 10−3	0.5357		0.68
21	CLIC3	4.0 × 10−8	0.118		0.85	67	KCNJ15	9.0 × 10−3	0.506		0.64
22	LRRC8B	4.4 × 10−8	0.459		0.90	68	CNGB3	1.0 × 10−2	0.63		0.69
23	HCN2	2.1 × 10−7	3.88		0.89	69	SCNN1D	1.0 × 10−2	0.735		0.69
24	TRPM1	3.0 × 10−7	0.368		0.77	70	GRIA4	1.2 × 10−2	0.71		0.68
25	BEST2	3.6 × 10−7	0.456		0.86	71	TRPM3	1.3 × 10−2	0.762		0.72
26	AQP3	6.9 × 10−7	0.067		0.97	72	CHRNA10	1.5 × 10−2	0.759		0.68
27	KCNN4	1.5 × 10−6	3.79		0.93	73	AQP9	1.9 × 10−2	0.56		0.75
28	SCN1B	1.5 × 10−6	0.657		0.83	74	VDAC3	1.9 × 10−2	1.27		0.78
29	LRRC8E	1.5 × 10−6	0.563		0.82	75	KCNV1	2.0 × 10−2	1.737		0.70
30	CACNB1	2.9 × 10−6	0.614		0.82	76	VDAC2	2.0 × 10−2	1.15		0.71
31	KCNJ12	3.5 × 10−6	0.388		0.80	77	CHRNB1	2.1 × 10−2	0.754		0.68
32	KCNJ18	3.5 × 10−6	0.388		0.80	78	ANO2	2.4 × 10−2	0.67		0.68
33	TRPM4	3.6 × 10−6	0.154		0.87	79	CHRNB2	2.6 × 10−2	1.383		0.70
34	KCNS3	7.7 × 10−6	0.403		0.93	80	SCNN1G	2.8 × 10−2	1.45		0.67
35	PKD2L1	8.7 × 10−6	2.66		0.86	81	TRPC6	2.8 × 10−2	0.594		0.67
36	P2RX4	1.0 × 10−5	1.756		0.85	82	KCNA1	3.0 × 10−2	0.79		0.67
37	GRIK2	3.9 × 10−5	3.922		0.86	83	PKD2L2	3.0 × 10−2	0.447		0.52
38	KCNJ4	5.0 × 10−5	2.87		0.84	84	GABRA6	3.9 × 10−2	0.622		0.65
39	TRPM2	6.5 × 10−5	0.219		0.93	85	GRINB2	3.9 × 10−2	1.225		0.67
40	CLCN7	1.2 × 10−4	1.753		0.80	86	KCNJ2	4.0 × 10−2	1.33		0.72
41	MCOLN3	2.2 × 10−4	0.352		0.62	87	TRPV5	4.0 × 10−2	1.29		0.66
42	SCN2B	2.6 × 10−4	0.483		0.71	88	ASIC1	4.1 × 10−2	0.71		0.63
43	LRRC8D	2.8 × 10−4	1.39		0.78	89	AQP5	4.1 × 10−2	1.498		0.67
44	MCOLN1	3.8 × 10−4	1.43		0.72	90	CACNG3	4.3 × 10−2	1.903		0.73
45	CLCN6	5.0 × 10−4	0.74		0.79	91	TRPC4	4.3 × 10−2	2.097		0.69
46	CNGA1	5.0 × 10−4	0.58		0.72