Figure 6.

Proposed model for ANXA2 regulation of AKT activation. (a) ANXA2 binds to and positively regulates the activity of PTEN. This mechanism might play a role in the regulation of H₂O₂-dependent signaling, e.g., EGFR/EGF or RAS, leading to inactivation of the PI3K/AKT signaling pathway. (b) In the absence of ANXA2, PTEN activity is inhibited leading to enhanced AKT activation. The activation of the EGFR/PI3K/AKT or RAS/PI3K/AKT signaling pathways enable Rac to bind and activate NADPH oxidase (NOX), ultimately leading to the production of H₂O₂. Increase in intracellular H₂O₂ levels induce PRDX2 up-regulation.