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. 2019 Apr 11;11(4):519. doi: 10.3390/cancers11040519

Table 3.

Enrichment by process networks of down-regulated genes.

Networks p-Value Genes Involved
Reproduction_Gonadotropin regulation 0.003 ATF-3, EGR1, HB-EGF, GABA-A receptor epsilon subunit, Adenylate cyclase, FosB, AKR1C3, c-Fos
Proteolysis_Connective tissue degradation 0.004 Matrilysin (MMP-7), Trypsin II, Trypsin, ADAM8, SERPINA3 (ACT), Protein C inhibitor
Reproduction_FSH-beta signaling pathway 0.004 EGR1, TGM2, Adenylate cyclase, VEGF-A, ActRIIB, c-Fos, IBP
Signal transduction_ESR1-membrane pathway 0.005 HB-EGF, Adenylate cyclase, Adenylate cyclase type IV, c-Fos, Caveolin-1
Development_Regulation of angiogenesis 0.007 Ephrin-A, Ephrin-A1, IL-15, Angiotensin II, HB-EGF, Angiogenin, VEGF-A, Angiotensin III
Signal transduction_WNT signaling 0.007 Matrilysin (MMP-7), HES1, WISP2, HB-EGF, Adenylate cyclase, VEGF-A, c-Fos