Figure 3.

Relative protein abundance of insulin signaling pathway in white adipose tissue. IRS, pT263 ^IRS1, AKT, and pS473^AKT in rats fed different sweeteners with or without high fat diet (A); phosphorylated IRS/total IRS ratio (B); phosphorylated AKT/total AKT ratio (C); relative expression of glucose transporter type 4 (GLUT 4) (D), GIP receptor (E) and sterol regulatory element-binding protein 1 (F). The data are expressed as the mean ± SEM (n = 6). Results were considered statistically significant at p < 0.05. Significant differences among groups are indicated by letters, where a > b > c > d > e.