Figure 1.

Maximum likelihood phylogenetic tree of Japanese HPV16 isolates. The phylogenetic tree was constructed using whole-genome sequences of 100 Japanese isolates obtained in this study, together with those of 14 Japanese isolates previously determined by us, one Thai isolate, and 10 reference strains for HPV16 variant (sub) lineages. Bootstrap values larger than 70% are displayed. Scale bar, nucleotide substitutions per site. A1, A2, A3, and A4: sublineages; B, C, and D: lineages. Gray area indicates a cluster of A5 variants.