Table 4.

Predictive performances of prediction models in derivation set (n = 921).

Time-Dependent AUROC (95% CI)
Year	SNAVCORN	ART	SNACOR	p-value	p-value
				SNAVCORN vs. ART	SNAVCORN vs. SNACOR
Year 1	0.812 (0.769–0.856)	0.588 (0.531–0.645)	0.762 (0.707–0.818)	<0.001	<0.001
Year 3	0.734 (0.396–0.770)	0.503 (0.462–0.545)	0.662 (0.621–0.704)	<0.001	<0.001
Year 5	0.700 (0.663–0.737)	0.490 (0.450–0.529)	0.634 (0.593–0.675)	<0.001	<0.001
	ABCR	HAP	mHAPII	p-value	p-value	p-value
				SNAVCORN vs. ABCR	SNAVCORN vs. HAP	SNAVCORN vs. mHAPII
Year 1	0.786 (0.728–0.844)	0.744 (0.698–0.790)	0.705 (0.655–0.756)	<0.001	<0.001	<0.001
Year 3	0.667 (0.609–0.725)	0.688 (0.650–0.725)	0.658 (0.619–0.696)	0.003	<0.001	<0.001
Year 5	0.617 (0.556–0.677)	0.644 (0.627–0.702)	0.650 (0.612–0.687)	<0.001	<0.001	<0.001

AUROC, area under receiver-operating characteristic curve; CI, confidence interval. SNAVCORN score features baseline tumor Size (≥5 cm), tumor Number (≥4), AFP level (≥400 ng/mL), presence of Vascular invasion, Child–Pugh score (≥6), the absence of Objective Response after TACE, and NLR (≥5); ART score features an increase in the AST level of >25%, an increase in the Child–Pugh score of 1 or 2 points from baseline, and the absence of a radiological tumor response; ABCR score features baseline AFP level (>200 ng/mL) and BCLC stage, a rise in the Child–Pugh score of ≥2 points from baseline, and the absence of a radiological Response; SNACOR model features tumor Size (≥5 cm), tumor Number (≥4), the baseline AFP level (≥400 ng/mL), Child–Pugh class B status, and the absence of an Objective radiological Response; HAP score features albumin (<36 g/dL), AFP level (>400 ng/mL), bilirubin (>17 μmol/L), and maximal tumor size (>7 cm); mHAP II score features albumin (<36 g/dL), AFP level (>400 ng/mL), bilirubin (>17 μmol/L), maximal tumor size (>7 cm), and tumor number (≥2).