Figure 5.

Combinatorial targeting of several signalling pathways. The figure shows the protein interaction analysis (https://string-db.org/) of IL-6, IL-8, VEGF-A and MFGE-8 (indicated by arrows). The circle delineates the SRC protein. Green nodes denote proteins associated with vascularisation, red nodes denote proteins of IL-6/STAT-3 and IL-8 signalling, and blue nodes denote proteins associated with resistance to hypoxia. The links in the diagram indicate experimental or literature association of the proteins. Links in the solid (or dashed) line indicate interactions within (or between) signalling pathways. MFGE-8 also plays a role in the interaction between cancer cells and tumour-associated macrophages (TAM).