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. 2019 Apr 14;11(4):532. doi: 10.3390/cancers11040532

Figure 1.

Figure 1

CD44 and CD44 splice variants. (a) CD44 is a transmembrane glycoprotein. CD44 consists of the extracellular domain, the transmembrane domain, and the cytoplasmic domain. The ligand binding/extracellular domain interacts with hyaluronic acid, osteopontin, chondroitin, collagen, and fibronectin. The CD44 cytoplasmic domain mediates transcription. (b) The CD44 gene consists of 20 exons. CD44 gene, exons 1–5 and 16–20 produce the standard isoform of CD44, referred to as the CD44 standard (CD44s). The remaining exons 6–15 are alternatively spliced and assembled with the ten exons contained in the CD44 standard isoform and are referred to as the CD44 variant isoforms (CD44v).