Table 2.
Combination indexes (CI) of cytostatics (OxPt, 5-FU, IRT) and NAR, XH, IXH, 6-PN, and 8-PN in SW480 and SW620 after 72 h exposition. CIs were calculated as a function of the fraction affected (Fa), which represents the percentage of growth inhibition (0.8 = 80%) and was evaluated using the NRU assay.
| Compound | SW480 | SW620 | ||||
|---|---|---|---|---|---|---|
| 5-FU | IRT | OxPt | 5-FU | IRT | OxPt | |
| XH | 1.90 | 0.96 | 5.12 | 1.43 | 1.33 | 2.07 |
| IXH | 1.50 | 1.20 | 1.20 | 1.35 | 3.43 | 5.30 |
| 6-PN | 4.80 | 0.86 | 3.20 | 1.30 | 0.88 | 0.38 |
| 8-PN | 0.86 | 0.64 | 0.98 | 1.29 | 1.52 | 2.18 |
| NAR | 1.70 | 0.64 | 0.95 | 0.93 | 0.59 | 1.05 |
CI value <1, CI = 1, and CI > 1 indicates synergism, additive effect, and antagonism, respectively.