Fig. 1. (A) Real-time PERS spectra taken from PEG/RGD/NLS/AuNCs-internalized HSC-3 cells while being treated with cisplatin (200 μM). (B) Schematic representation showing the enzymatic conversion of heme by HO-1. (C and D) are the enlarged views of the PERS spectra showing the disulfide vibration (∼504 cm–1) in proteins and νCO (∼2115 cm–1) in CO. Two possible metal carbonyl interactions are also shown in panel (D).
